Penn Bioethics Seminar Series (PBS): "Brain Ultrasound for the Evaluation of Infants HIV-Exposed Uninfected in Botswana" led by Hansel J. Otero, MD, FAAP

12:00pm - 1:00pm • Hybrid: 1402 Blockley Hall, 423 Guardian Drive (and virtual via Zoom)

2024-10-22 12:00:00 2024-10-22 13:00:00 America/New_York Penn Bioethics Seminar Series (PBS): "Brain Ultrasound for the Evaluation of Infants HIV-Exposed Uninfected in Botswana" led by Hansel J. Otero, MD, FAAP Brain Ultrasound for the Evaluation of Infants HIV-Exposed Uninfected in Botswana Hansel J. Otero, MD, FAAP Vice Chair of Clinical Research, Department of Radiology Children's Hospital of Philadelphia Nearly one million infants are born HIV-exposed uninfected (HEU) annually worldwide and these infants are at risk for poor neurocognitive and developmental outcomes compared to infants born to persons without HIV. A viable and scalable screening mechanism is urgently needed to identify infants and young children who are HEU and in need of early interventions to reach their full neurocognitive and developmental potential. We piloted the used of basic infant brain ultrasound imaging to assess for structural differences that can identify infants who are HEU and at-risk for poor developmental outcomes. We have now plans to scale up the project to include advanced ultrasound technologies and correlate the findings with magnetic resonance imaging at 1-year of life and assessing for associations with neurodevelopmental outcomes, as measured by the Malawi Developmental Assessment Tool, at 2-years of life in this Botswana-based study. Lunch provided. Streaming available via Zoom. Hybrid: 1402 Blockley Hall, 423 Guardian Drive (and virtual via Zoom) Penn Medical Ethics

Nearly one million infants are born HIV-exposed uninfected (HEU) annually worldwide and these infants are at risk for poor neurocognitive and developmental outcomes compared to infants born to persons without HIV. A viable and scalable screening mechanism is urgently needed to identify infants and young children who are HEU and in need of early interventions to reach their full neurocognitive and developmental potential. We piloted the used of basic infant brain ultrasound imaging to assess for structural differences that can identify infants who are HEU and at-risk for poor developmental outcomes. We have now plans to scale up the project to include advanced ultrasound technologies and correlate the findings with magnetic resonance imaging at 1-year of life and assessing for associations with neurodevelopmental outcomes, as measured by the Malawi Developmental Assessment Tool, at 2-years of life in this Botswana-based study.