Research Ethics and Policy Series (REPS)

february 3, 2020

Ethical issues in the design & conduct of community-based research

The challenges of balancing scientific rigor and ethical concerns in community-engaged research are unique and complex. Ethical issues can arise in terms of methodology, research implementation, and practical aspects of community-based research. This talk will introduce ethical issues related to communities/stakeholders, research participants, and professional relationships with illustrations from case studies and an introduction to useful resources.

Karen Glanz, PhD, MPH
George A. Weiss University Professor
Perelman School of Medicine and School of Nursing

Research Ethics and Policy Issues: Karen Glanz, PhD, MPH

january 6, 2020

The ethics of genomics research involving indigenous populations in Africa

Supplemental readings and commentary:

Sarah Tishkoff, PhD
David and Lyn Silfen University Professor,
Departments of Genetics & Biology, Perelman School of Medicine

Commentary by Kellie Owens, PhD
Fellow, Medical Ethics & Health Policy, Perelman School of Medicine

UPenn Research Ethics and Policy Series (REPS): Sarah Tishkoff, PhD

DEcember 2, 2019 

Defining and Advancing IRB Quality and Effectiveness

Do you think institutional review boards (IRBs) “work”? What does that mean and how would we know? It turns out that evaluating IRB quality and effectiveness beyond superficial measurements related to compliance and efficiency is remarkably challenging. Nonetheless, it is essential to determining whether the system’s overall benefits outweigh its burdens, as well as what adjustments might be in order. In this lecture, Holly Fernandez Lynch describes the problem and introduces several novel approaches currently being pursued by the Consortium to Advance Effective Research Ethics Oversight (AEREO).

Holly Fernandez Lynch, JD, MBe
John Russell Dickson, MD Presidential Assistant
Professor of Medical Ethics, Medical Ethics & Health Policy, Perelman School of Medicine

UPenn Research Ethics and Policy Series (REPS): Holly Fernandez Lynch, JD, MBe

October 7, 2019 

Gene editing and geopolitics

The controversy about the gene edited babies in China happens to have coincided with increasing tensions between the US and China and intensified competition in the life sciences, including legal action against some Chinese scientists based in the US. In this talk I sketch out the background geopolitical issues that have received little attention but that provide context for the regulation of CRISPR and related technologies.

Jonathan D. Moreno, PhD
David and Lyn Silfen University Professor of Ethics,
Medical Ethics and Health Policy, Perelman School of Medicine

UPenn Research Ethics and Policy Series (REPS): Jonathan D. Moreno, PhD

JUNE 3, 2019 

Consent for clinical research in emergency settings: Patient-centered or pointless?

Informed consent for clinical research in the context of acute and emergent illness is widely recognized as challenging and is often not possible. There is, however, a wide spectrum of acute and emergent conditions and a similarly wide range of potential for patients and surrogates to engage in decisions about research enrollment. Dr. Dickert will focus on research designed to understand and integrate patients’ and surrogates’ perspectives on consent for clinical trials in the context of acute myocardial infarction and stroke. He will argue that involving patients and surrogates in enrollment decisions in many emergency situations is not pointless despite important limitations that must be recognized.

Neal Dickert, MD, PhD, FACC
Assistant Professor, Emory University School of Medicine
Department of Medicine, Division of Cardiology, ECCRI
Emory University Rollins School of Public Health,
Department of Epidemiology, Emory Center for Ethics

UPenn Research Ethics and Policy Series (REPS): Neal Dickert, MD, PhD, FACC

Commentary by Benjamin S. Abella, MD, MPhil, FAHA
Professor and Vice Chair for Research
Director, Center for Resuscitation Science
Department of Emergency Medicine
Perelman School of Medicine

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