March
7

Research Ethics and Policy Series: F. Claire Hankenson, DVM, MS, DACLAM

12:00pm - 1:00pm • Hybrid: BRB0251 (Biomedical Research Building, 421 Curie Blvd) and virtual via Zoom

2022-03-07 12:00:00 2022-03-07 13:00:00 America/New_York Research Ethics and Policy Series: F. Claire Hankenson, DVM, MS, DACLAM (R)Evolution of the 3Rs: Reflections on Art, Ethics, and Science   F. Claire Hankenson, DVM, MS, DACLAM Associate Vice Provost for Research Executive Director of University Laboratory Animal Resources (ULAR) & Attending Veterinarian Professor of Laboratory Animal Medicine, Dept of Pathobiology; School of Veterinary Medicine, University of Pennsylvania Hybrid event (In-person and via Zoom) ***NEW LOCATION*** BRB0251 (Biomedical Research Building, 421 Curie Blvd, Philadelphia, PA 19104) Abstract: The 3Rs serve as a universal touchstone, with respect to refinement, reduction, and replacement, for veterinary staff, ethical review committees and scientists. Russell and Burch established these terms as part of a new applied science in 1959, aiming to improve animal welfare using application of the 3Rs as a development tool for scientific methodology. In consideration of animal use, the anticipated benefits of scientific inquiry are to be balanced against the potential impacts borne by the animals themselves; this ethical calculation is referred to as the ‘harm-benefit’ analysis. Over time, rigid interpretations of the classic 3Rs in study design (refinement), statistical analysis (reduction), and selection of alternatives to live animals (replacement) have stifled the spirit of their initial intent and limited scientific progress and production of translatable and reproducible results. The exquisiteness of the 3Rs is that much like classical artwork, they are inherently subject to broad interpretation across the contemporary biomedical community. Reconsidering the classic 3Rs with progressive interpretations, in combination with other ethical tools of analysis and validity assessments, is essential for ongoing intricate considerations of appropriate and future animal use. Information: Mary Pham, Mary.Pham@pennmedicine.upenn.edu  Hybrid: BRB0251 (Biomedical Research Building, 421 Curie Blvd) and virtual via Zoom Penn Medical Ethics

(R)Evolution of the 3Rs: Reflections on Art, Ethics, and Science

 

F. Claire Hankenson, DVM, MS, DACLAM
Associate Vice Provost for Research
Executive Director of University Laboratory Animal Resources (ULAR) & Attending Veterinarian
Professor of Laboratory Animal Medicine, Dept of Pathobiology; School of Veterinary Medicine, University of Pennsylvania

Hybrid event (In-person and via Zoom)
***NEW LOCATION***

BRB0251 (Biomedical Research Building, 421 Curie Blvd, Philadelphia, PA 19104)

Abstract: The 3Rs serve as a universal touchstone, with respect to refinement, reduction, and replacement, for veterinary staff, ethical review committees and scientists. Russell and Burch established these terms as part of a new applied science in 1959, aiming to improve animal welfare using application of the 3Rs as a development tool for scientific methodology. In consideration of animal use, the anticipated benefits of scientific inquiry are to be balanced against the potential impacts borne by the animals themselves; this ethical calculation is referred to as the ‘harm-benefit’ analysis. Over time, rigid interpretations of the classic 3Rs in study design (refinement), statistical analysis (reduction), and selection of alternatives to live animals (replacement) have stifled the spirit of their initial intent and limited scientific progress and production of translatable and reproducible results. The exquisiteness of the 3Rs is that much like classical artwork, they are inherently subject to broad interpretation across the contemporary biomedical community. Reconsidering the classic 3Rs with progressive interpretations, in combination with other ethical tools of analysis and validity assessments, is essential for ongoing intricate considerations of appropriate and future animal use.

Information: Mary Pham, Mary.Pham@pennmedicine.upenn.edu 

Loading tweets...